PARTNER 1 – FORTH (IESL)

 

Address:
Institute of Electronic Structure and Laser,

P.O. Box 1527,

GR-711 10 Heraklion,

Greece.

Telephone: ++30-2810-391547

Fax: ++30-2810-391305

Email: jripoll@iesl.forth.gr

Webpage: www.iesl.forth.gr  

 

Members

Name

Email

Telephone

Jorge Ripoll

jripoll@iesl.forth.gr

+30 2810 391547

Giannis Zacharakis

zahari@iesl.forth.gr

+30 2810 391129

Anikitos Garofalakis

agarof@iesl.forth.gr

+30 2810 391345

Heiko Meyer

heimeyer@iesl.forth.gr

+30 2810 391345

 

Main Research Activities

Our research activities concern the development and application of tomographic technologies for the in-vivo imaging of biomolecular function in living systems. We are interested in the noninvasive visualization of specific molecular targets and pathways by exploiting the fluorescence signal emitted by fluorescent probes attached to cells or molecules. An important aspect of our research concerns the analysis of images taken by the system into three-dimensional maps of fluorescent concentration. This technique, which is called Fluorescence-mediated Molecular Tomography (FMT) developed by the international collaborator LBMI  can measure and characterize specific molecular processes, and thus answers can be given in particular biological questions concerning disease development or drug delivery. Another experimental activity is the characterization of both human and mice tissue via time-resolved spectroscopy. In addition, theoretical research concerns the development of novel theoretical tools that model light propagation in tissue-like media. The tomographic system for the in-vivo imaging of mice is shown in the figure.

 

Main activities

 

  • Optical Tomography

 

  • Optical Characterization and Spectroscopy

 

  • Image Analysis

 

  • Engineering of Novel Imaging Setups

 

  • Theoretical Developments (Light Diffusion and Multiple Scattering, Tomography, Photobleaching Experiments)

 

 

Most Relevant Publications

1.      Ntziachristos V, Ripoll J, Wang L, Weissleder R., “Looking and listening to light: the revolution of photonic imaging” Nature Biotechnology 23(3): 313-320 (2005).

2.      A. Garofalakis, G. Zacharakis, G. Filippidis, E. Sanidas, D. D. Tsiftsis, V. Ntziachristos, T. G. Papazoglou and J. Ripoll, “Characterization of the reduced scattering coefficient of optically thin samples: theory and experiments”, Journal of Optics A: Pure Appl. Opt. 6 725-735 (2004)

3.      J. Ripoll, D. Yessayan, G. Zacharakis, V. Ntziachristos, “Experimental determination of photon propagation in highly absorbing and scattering media”, JOSA A 22, 1-6 (2005)

4.      J. Ripoll and V. Ntziachristos: “Imaging scattering media from a distance: Theory and applications of non-contact optical tomography”, Mod. Phys. Lett. B (2004).