|
PARTNER 17-4 DIO Prof. Miguel Torres |
|
|
Address: Departamento
de Inmunología y Oncología Centro
Nacional de Biotecnología Darwin,
3. Campus
de Cantoblanco 28049
Madrid, |
|
Telephone: +34
915854849 |
|
Fax: +34
913720493 |
|
Email: mtorres@cnb.uam.es |
|
Webpage: http://www.cnb.uam.es/~mtorres/ |
Members
|
Name |
Email |
Telephone |
|
Miguel Torres |
+34915854849 |
|
|
Juan José Sanz Ezquerro |
+34915854664 |
|
|
Roisin Doohan |
+34915854665 |
|
Main
Research Activities We aim to understand how complex organs are
patterned during development and regeneration in higher vertebrates. We mainly use the tetrapod limb as a model
to answer this general question.
Classical studies have initially approached the problem by
experimental embryological methods and later, by deciphering regulatory gene
pathways and describing the consequences of their massive gain- or
loss-of-function. Despite the
important amount of information accumulated, how the regulatory genes control
basic cellular mechanisms -such as migration, adhesion, division, death- in
time and space to generate complex organ architectures remains largely
unknown. We want to extend the level
of analysis one step beyond by analyzing how these basic cellular properties
are regionally regulated during organ formation by the regulatory genes, and
by determining what is the impact of each basic cellular
property in patterning the complete structure. |
|
Most
Relevant Publications N. Mercader, E. Leonardo, N. Azpiazu, A. Serrano, G.
Morata, C. Martínez-A and M. Torres (1999). Conserved regulation of
proximodistal limb axis development by Meis1/Hth. Nature, 402, 425-429. N.
Mercader, E. Leonardo, M. E. Piedra, C. Martínez-A, M. Á. Ros and M. Torres
(2000). Opposing RA and FGF signals control proximodistal vertebrate
limb development through regulation of Meis genes. Development, 127, 3961-3970 C.
Clavería, E. Caminero, , C. Martínez-A , S.
Campuzano and M. Torres (2002). GH3, a novel proapoptotic domain in
Drosophila Grim, promotes a mitochondrial death pathway. EMBO J. 21, 3327-3336 M.Torres, J.P. Couso and M. Ros (2002) Building Limb
Buds. EMBO Reports, 10, 933-937 Cristina
Clavería, Carlos Martínez-A and Miguel Torres (2004). A
Bax/Bak-independent mitochondrial death pathway triggered by Drosophila Grim
GH3 domain in mammalian cells JBC
279, 1368-75 Valeria Azcoitia, Miguel Aracil, Carlos Martínez-A
and Miguel Torres (2005) The homeodomain protein Meis1 is essential for
definitive hematopoiesis and vascular patterning in the mouse embryo Dev. Biol. In press |