PARTNER 17-1 Centro Nacional de Biotecnologia Prof. Carlos Martinez

Address:

Centro Nacional de Biotecnologia

Campus de Cantoblanco

28049 Madrid

Telephone: +34 91 585 4850

Fax: +34 91 372 0493

Email: cmartineza@cnb.uam.es

Webpage: http://dio.cnb.uam.es/

Members

Name	Email	Telephone
Mario Mellado	mmellado@cnb.uam.es	+34 91 585 4660
José Miguel Rodríguez	jmrfrade@cnb.uam.es	+34 91 585 4660

Main Research Activities

Inflammation, Chemokines, signaling, GPCR conformations

Most Relevant Publications

B. Molon, G. Gri, M. Bettella, C. Gomez-Mouton, A. Lanzavecchia, C. Martinez-A,

S. Manes and A. Viola (2005). T cell costimulation by chemochine receptors.

Nature Immunol., in press.

Hernanz-Falcón P., Rodríguez-Frade J.M., Serrano A., Juan D., del Sol A., Soriano S.F., Roncal F., Gómez L., Valencia A., Martínez-A. C. and Mellado M. (2004). Identification of amino acid residues critical for chemokine receptor dimerization. Nat. Immunol. 5:216-223.

Rodríguez-Frade J.M., del Real G., Serrano A., Hernanz-Falcón P., Soriano S.F., Vila-Coro A.J., Martín de Ana A., Lucas P., Prieto I., Martínez-A. C. and Mellado M. (2004). Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. EMBO J. 23:66-76.

Garzón R, S.F., Rodríguez-Frade J.M. Gómez L., de Ana A.M., Sánchez-Gómez M., Soriano Martínez-A. C. and Mellado M. (2004). CXCR4-mediated SOCS upregulation inactivates growth hormone function. J. Biol. Chem. 279:44460-44466

Nombela-Arrieta C, RA Lacalle, MC Montoya, Y Kunisaki, D Megias, M Marques, AC Carrera, S Manes, Y Fukui, C Martínez-A & JV Stein. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 21, 429-441. (2004)

Carvalho-Pinto C., García M.I.,Gómez L., Ballesteros A., Zaballos A., Flores J.M., Mellado M., Rodríguez-Frade J.M., Balonmenos D. and Martínez-A. C. (2004). Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic (NOD) mice. Eur. J. Immunol. 34:548-557.

Gómez-Moutón, C., Lacalle, R.A., Mira, E., Jiménez-Baranda, S., Barber, D.F., Carrera, A.C., Martínez-A., C., Mañes, S. Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J. Cell Biol. 164:759-768 (2004)

del Real, G., Jiménez-Baranda, S., Mira, E., Lacalle, R.A., Lucas, P., Gómez-Moutón, C., Alegret, M., Peña, J.M., Rodríguez-Zapata, M., Álvarez-Mon, M., Martínez-A., C., Mañes, S. Statins inhibit HIV-1 infection by down-regulating Rho activity. J. Exp. Med. 200:541-547 (2004)

Mañes, S., Martínez-A., C. Cholesterol domains regulate the actin cytoskeleton at the leading edge of moving cells. Trends Cell Biol. 14:275-278 (2004)

Mañes, S., del Real, G., Martínez-A., C. Pathogens: Raft hijackers. Nature Rev. Immunol. 3:557-568 (2003)

Mañes, S., Mira, E., Colomer, R., Montero, S., Real, L.M., Gómez-Moutón, C., Jiménez-Baranda, S., Garzón, A., Lacalle, R.A., Harshman, K., Ruíz, A., Martínez-A., C. CCR5 expression influences the progression of human breast cancer in a p53-dependent manner. J. Exp. Med. 198:1381-1389 (2003)

Stein JV, SF Soriano, C M’rini, C Nombela-Arrieta, GG de Buitrago, JM Rodríguez-Frade, M Mellado, JP Girard & C Martínez-A. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood 101, 38-44. (2003)

S. F Soriano, A. Serrano, P. Hernanz-Falcón, A. Martín de Ana, M. Monterrubio, C. Martínez-A, J. M. Rodríguez-Frade and M. Mellado.(2003). Chemokines integrate JAK/STAT and G-protein pathways during chemotaxis and calcium flux responses. Eur. J. Immunol. 33:1328-1333.